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pentobarbital will lower the extent or impact of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers could enhance the metabolism of ifosfamide to its Lively alk